Description
The maternal serum screen (Double, Triple, Quadruple Marker) is a blood test performed during pregnancy to assess the risk of certain genetic conditions and birth defects in the fetus, such as Down syndrome, Trisomy 18, and neural tube defects.
How the Test is Done?
A small sample of blood is drawn from the mother and analyzed to measure the levels of specific substances (markers) in the blood:
- Double Marker: measures free beta-hCG and PAPP-A.
- Triple Marker: measures hCG, AFP, and estriol.
- Quadruple Marker: measures hCG, AFP, estriol, and inhibin-A.
These markers help assess the likelihood of genetic abnormalities in the fetus.
Preparation Required
No special preparation is required for the test. It is typically done between the 11th and 20th weeks of pregnancy. However, your doctor may suggest avoiding certain medications before the test, depending on individual circumstances.
Significance of the Results
The results of the maternal serum screen indicate the risk level for genetic conditions like Down syndrome or neural tube defects. Abnormal results don’t confirm a condition but indicate a higher risk, prompting further diagnostic tests like amniocentesis or ultrasound for more definitive results. This test helps expectant parents make informed decisions about further testing and pregnancy management.
